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sparsentan will lower the level or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and lowers efficacy associated with these substrates.modafinil will improve the degree or impact of diazepam intranasal by impacting hepatic enzyme